The complete practice of EGM comprises five steps, and this book addresses each in turn:

Step 1: Converting the need for information (about prevention, diagnosis, prognosis, therapy, causation, etc.) into an answerable question.
Step 2: Tracking down the best evidence with which to answer that question.
Step 3: Critically appraising that evidence for its validity, impact, and applicability.
Step 4: Integrating the critical appraisal with our clinical expertise and with our patient’s unique biology, values and circumstances.
Step 5: Evaluating our effectiveness and efficiency in executing Steps 1-4, and seeking ways to improve them both for next time.