Endocrinology

Condition or Disorder	Intervention vs. Control	Outcome	Follow-up Duration	Event Rates %		NNT (95% CI)
				CER	EER
Graves Hyperthyroidism1	Radioiodine and prednisone vs. radioiodine therapy	Development and improvement of opthalmopathy	1 year	15	0	7 (5 to 11)
Type 2 diabetes mellitus in overweight patients2	Radioiodine and prednisone vs. radioiodine therapy	Diabetes related end point	10 years	39	29	10 (6 to 29)
		Deaths from diabetes		13	8>	19 (10 to 138)
		All cause mortality		22	15	14 (8 to 67)
		MI		18	11	16 (9 to 78)
Diabetic men with erectile dysfunction3	Sildenafil vs. placebo	Improved erections	12 weeks	10.2	56.5	3 (2 to 3)
“Insulin requiring” diabetes4	Regular telephone contact with a diabetes nurse educator for advice about adjustment of insulin therapy vs. regular clinic visits and usual contact with the endocrinologist for insulin adjustment	Mean HbAlc level and proportion of patients who achieved a reduction in HbAlc level ≥ 10%	6 months	35	87	2 (1 to 4)

References

---

1. N Engl J Med 1998 Jan 8;338(2):73-8 
2. Lancet 1998 Sep 12;352(9131):854-65 
3. JAMA 1999 Feb 3;281(5):421-6 
4. CMAJ. 19 Oct 1999; 161: 959-62