Gastrointestinal

Condition or Disorder	Intervention vs. Control	Outcome	Follow-up Duration	Event Rates %		NNT (95% CI)
				CER	EER
Endoscopic re-treatment of bleeding peptic ulcer1	Endoscopy vs. surgery	Mortality at 30 days, duration of hospitalization after treatment, ICU stay, need for blood transfusion and treatment-related complications	6 weeks	36	15	5 (3 to 25)
Remission rates in active Crohn disease2	Budesonide vs. mesalamine	Remission	16 weeks	36	62	4 (3 to 10)
Endoscopic gastroduodenal ulcers in osteoarthritis3	Rofecoxib vs. Ibuprofen	Endoscopic gastroduodenal ulcers ≥ 3 mm at 12 weeks	24 weeks	7	25	5 (4 to 9)
Women with irritable bowel syndrome4	Alosetron vs. placebo	Relief of abdominal symptoms	1 month	29	41	8 (5 to 22)
		Constipation		3	30	4 (3 to 5)
Bleeding peptic ulcer5	Omeprazole vs. placebo	Recurrent bleeding	8 weeks	22.5	6.7	6 (4 to 14)
		Hospital stay < 5 days		31.7	46.7	7 (4 to 38)
H pylori infection6	Clarithromycin. Iansoprazole, metronidazole vs clarithromycin, Iasoprazole, amoxicillin	Eradication of H pylori	6 weeks	84	66	6 (3 to infinity)

References

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1. Gastroenterology. Oct 1999; 117: 776-83 
2. N Engl J Med. 6 Aug 1998; 339: 370-4 
3. N Engl J Med. 6 Aug 1998; 339: 370-4 
4. Lancet. Mar 25, 2000; 355:1035-40 
5. N Engl J Med. Aug 3, 2000; 343: 310-6 
6. JAMA. 2003;290:1593-9