Reviewers should discuss the quality, strength, and applicability of the evidence for each main outcome when summarizing the results. The Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach is a framework that can be used to facilitate interpretation of results, and has been endorsed by the Cochrane Collaboration. Qualitative evidence may also help to interpret how the intervention works, determine whether it could work in different settings, identify facilitators and barriers to implementing the intervention, and highlight subjective experience of patients receiving the intervention. Reviewers should consider both study-level and review-level limitations. The Assessment of Multiple SysTemAtic Reviews (AMSTAR) tool can be used to identify limitations in the systematic review process, which should be noted. Finally, reviewers should carefully draw conclusions based on the available evidence.